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How to Layer Peptide Serums: A Simple Guide
2026-04-28// Research Archive

How to Layer Peptide Serums: A Simple Guide

Got a few of our serums and not sure what order to use them in? Here are three simple rules for layering peptides so each one actually works.

Once you've got a couple of our serums, the obvious question is: what order do I put them on, and can I use them together? It's a fair thing to ask — with high-strength peptides, the order really does change how well they work. Here are three simple rules that take the guesswork out of it.

Rule one: thinnest to thickest

Our serums are water-based and deliberately light, so they absorb fast. Always apply the most watery one first and work up to anything richer. A thin serum can't push through a heavy cream, but it soaks straight into clean skin in seconds.

Rule two: keep acids and copper peptides apart

Strong acids — high-strength vitamin C, glycolic, salicylic — don't mix with copper peptides like GHK-Cu. Put them together and they cancel each other out, and you've wasted both. Use acids in the morning and your copper peptides at night, or leave at least 30 minutes between them.

Rule three: give each layer a moment

You don't need to wait ages, but let each serum settle for a minute before the next. Applying to slightly damp skin helps the peptides travel; sealing everything at the end with a moisturiser or a richer artifact like Aegis keeps it all where it should be.

A simple routine that works

If you want a no-fuss starting point: repair serum (War Paint or Northern Light) first, then a smoothing one (Frost or Crystal), then anything for volume or barrier on top. Same order morning and night. Consistency is where the results come from — a simple routine you actually keep to beats a complicated one you abandon.